Constructed by Winnsboro merchant and civic leader, R.E. Skeen, proprietor of a drug, jewelry, general merchandise, and bank business.   When constructed, Skeen incorporated the two story structure at the rear, built by his brother, Dr. Titus Skeen in 1890 as a medical clinic and pharmacy. Skeen Building housed a general merchandise and clothing business from 1901-1984.  The Skeen Building also served as a drug store and pharmacy. 2013 - Peter and Janice Schma acquired the Skeen Building, and restored the structure to its original stature.